✦ LIBER ✦
A novel o-quinodimethane strategy for an active metabolite of vitamin D3. A total synthesis of 25-hydroxy Windaus-Grundmann ketone
✍ Scribed by Hideo Nemoto; Masahiro Ando; Keiichiro Fukumoto
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 231 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A highly diastereoselective total synthesis of 25-hydroxy Windaus-Grundmann ketone (2) was achieved via a novel regiocontrolled C-C bond formation by an intramolecular epoxide ring opening reaction of the bissulfonyl epoxide (19) as a key step, which was derived stereoselectively by the thermolysis of