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A novel NADP+-dependent dehydrogenase activity for 7α/β- and 11β-hydroxysteroids in human liver nuclei: A third 11β-hydroxysteroid dehydrogenase

✍ Scribed by B. Robinzon; R.A. Prough


Book ID
116178435
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
447 KB
Volume
486
Category
Article
ISSN
0003-9861

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## Abstract The human placental 11β‐hydroxysteroid dehydrogenase type 2 (11β‐HSD2) is believed to play a key role in fetal development since this enzyme protects the fetus from exposure to high levels of maternal cortisol by virtue of converting maternal cortisol to its inert metabolite cortisone.