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A novel mutation in the signal transducer and activator of transcription 3 (STAT3) gene, in hyper-IgE syndrome

✍ Scribed by Anastasios D. Papanastasiou; Stefanos Mantagos; Dimitrios A. Papanastasiou; Ioannis K. Zarkadis

Book ID: 116757638
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 672 KB
Volume: 47
Category: Article
ISSN: 0161-5890
DOI: 10.1016/j.molimm.2010.01.010

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## Abstract Signal transducer and activator of transcription 3 (Stat3) is one of a family of cytoplasmic proteins that participate in normal cellular responses to cytokines and growth factors as transcription factors. Stat3 modulates various physiological functions including cell survival, cell‐cyc