𝔖 Bobbio Scriptorium
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A novel mouse model for segmental orthotopic colon cancer

✍ Scribed by Herlen Alencar; Ray King; Martin Funovics; Charles Stout; Ralph Weissleder; Umar Mahmood

Publisher
John Wiley and Sons
Year
2005
Tongue
French
Weight
274 KB
Volume
117
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Spontaneous colon tumor mouse strains offer numerous advantages in modeling disease. However, the wide temporal window in which lesions form and the stochastic nature of lesion location require larger cohorts for assessment of disease modulation. Reliable, reproducible and inexpensive mouse models of early‐stage and invasive cancer would add to existing transgenic models. We show a new method for the creation of orthotopic murine tumors centered in the mucosal and submucosal layers anywhere in the colon, allowing creation of lesions of known age, location and extent. The system overcomes the disadvantages of heterotopic implantation and allows evaluation of lesions distally in the colon as well as proximally, thereby providing an additional method to study the effects of regionality. Invasion, host vascularization and application to disparate cell lines are demonstrated. Noninvasive imaging with magnetic resonance and colonoscopy, allowed in part by the tumor location, show potential applications of this approach. Β© 2005 Wiley‐Liss, Inc.

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