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A novel monoclonal antibody against carbohydrates of L1 cell adhesion molecule causes an influx of calcium in cultured cortical neurons

โœ Scribed by Kouichi Itoh; Hideki Kawamura; Hiroaki Asou

Book ID
115803027
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
973 KB
Volume
580
Category
Article
ISSN
0006-8993

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Monoclonal antibody that recognizes the
Monoclonal antibody that recognizes the carbohydrate portion of cell adhesion molecule L1 influences calcium current in cultured neurons
โœ Hiroaki Asou ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 796 KB

A monoclonal antibody (mAb), 2E12, against the neural cell adhesion molecule L1 recognized the 200 kDa component of L1. The epitope of L1 reacting with mAb 2E12 was localized in its carbohydrate chain, judging from the results o C experiments on glycopeptidase F treatment. The physiological effect o