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A novel micelle-encapsulated platinum(II) anticancer agent

โœ Scribed by Vithal B. Jadhav; Yong Joo Jun; Ju Hee Song; Min Kyoung Park; Ji Hyun Oh; Song Wha Chae; In-Sun Kim; Soo-Jin Choi; Hwa Jeong Lee; Youn Soo Sohn


Book ID
113693477
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
518 KB
Volume
147
Category
Article
ISSN
0168-3659

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Herceptinโ€“Platinum(II) Binding Complexes
โœ Jian Gao; Ya Guang Liu; Renbin Liu; Ralphโ€…A. Zingaro ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 640 KB

## Abstract We report a new series of Herceptinโ€“platinum(II) binding complexes, Herโ€“__n__LPt^II^ (Her denotes Herceptin; L denotes diamino ligands and L=L1โ€“L4; __n__=1, 5, or 10). Solution chemistry studies have shown that these complexes are stable under physiological conditions (pHโ€…7.4 in PBS). T