A novel method to synthesize (L)-β-hydroxyl esters by the reduction with bakers' yeast

A new method for stereochemical control

A new method for stereochemical control of microbial reduction. Reduction of β-keto esters with bakers' yeast immobilized by magnesium alginate

✍ Kaoru Nakamura; Yasushi Kawai; Shinzaburo Oka; Atsuyoshi Ohno 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 148 KB

Yeast reduction of methyl 3-oxnpcntanoate gives the L-hydroxy ester when bakers' yeast is immobilized by magnesium alginate and the reaction is run under a high concentration of magnesium ion. The D-hydroxy ester is obtained under normal reaction conditions. Asymmetric reduction of ketones by yeast