A novel method forN-alkylation of aliphatic amines with ethers over γ-Al2O3

✍ Scribed by Hangeng Chen; Tao Zhang; Chao Qian; Xinzhi Chen

• Book ID: 111491368
• Publisher: Versita
• Year: 2010
• Tongue: English
• Weight: 251 KB
• Volume: 64
• Category: Article
• ISSN: 0366-6352
• DOI: 10.2478/s11696-010-0033-7

✦ Synopsis

Abstract

A novel and simple method for the N-alkylation of amines with different ethers as alkylating reagents has been developed, using cheap γ-Al2O3 as the catalyst at atmospheric pressure in the temperature range of 260–320°C. For example, the reaction of equimolar amounts of morpholine and diethyl ether gave N-ethylmorpholine quantitatively. The present catalytic system is applicable to the N-alkylation of both primary and secondary amines. Since only water is generated as byproduct, the protocol proved to be eco-friendly and atom-economic.