A novel method for the formation of 2-azocanones by lactone-to-lactam ring contraction of 2-oxonanones
β Scribed by Sam Derrer; Neil Feeder; Simon J. Teat; John E. Davies; Andrew B. Holmes
- Book ID
- 104260259
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 229 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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Samarium(II) diiodide-mediated reductive cross-coupling of N-alkylated phthalimides with carbonyl compounds is shown to afford hydroxylated Ξ±-hydroxylactams. Ketoamides obtained by dehydration of these compounds through keto-enol tautomer isomerization were reduced with NaBH 4 in a completely stereo