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A novel method for the detection of down syndrome with the use of four serum markers

✍ Scribed by Masaki Azuma; Ritsu Yamamoto; Yukio Wakui; Shinichiro Minobe; Shinji Satomura; Seiichiro Fujimoto


Book ID
114487800
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
55 KB
Volume
187
Category
Article
ISSN
1097-6868

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The proform of eosinophil major basic protein (proMBP), the most abundant protein in the eosinophil specific granule, is synthesized by the placenta and secreted into the maternal circulation, where it is found complex-bound to pregnancy-associated plasma protein-A (PAPP-A) and other proteins. We ex