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A novel method for synthesis of unsymmetrical sulfides from alcohols and thiols by utilizing aminophosphonium salts

โœ Scribed by Yoshio Tanigawa; Hiroshi Kanamaru; Shun-Ichi Murahashi

Publisher
Elsevier Science
Year
1975
Tongue
French
Weight
218 KB
Volume
16
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Sulfides have been received much attention because of its potential utilities,' and various methods for synthesis of sulfides have been explored.2 Their major processes require halides which are often derived from alcohols, however, halides bearing allyl, cyclopropyl, and propargyl groups are hardly accessible, since such functional groups are liable to rearrange during a course of halogenation of alcohols.3 We now wish to report a novel and efficient method for synthesis of unsymmetrical sulfides from alcohols and thiols in a single step by utilizing N,N-methylphenylaminotriphenylphosphonium iodide Ph3PtN(CH3)Ph I-(1)4 as depicted in eq 1, where the reaction proceeds with complete N inversion of configuration.

๐Ÿ“œ SIMILAR VOLUMES

A novel method for synthesis of unsymmet
A novel method for synthesis of unsymmetrical secondary and tertiary amines from reactions of alcohols with amines by utilizing aminophosphonium salts
โœ Yoshio Tanigawa; Shun-Ichi Murahashi; Ichiro Moritani ๐Ÿ“‚ Article ๐Ÿ“… 1975 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 84 KB

secondary amlnes by palladium catalyst was explored (1). We now wish to report a novel method for synthesis of these amlnes from alcohols by utlllzlng versatile aminophosphomum reagent Ph3P+NR1R2 X-(.) (2). This method has certain advantages over the previous methods for