A novel method for synthesis of chitobiose via enzymatic glycosylation using a sugar oxazoline as glycosyl donor
β Scribed by Shiro Kobayashi; Toshitsugu Kiyosada; Shin-ichiro Shoda
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 123 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
A convenient method for synthesis of N,N'-diacetylchitobiose, an important building block for oligo and polysaccharide synthesis, has been developed by using a 1,2-oxagoline derivative of Nacetylglucosamine as new glycosyl donor for chitinase.
π SIMILAR VOLUMES
Trichloroacetimidate at 1 and 3 position of 4.6-benzylidenyl N-acetylgalactosamine serves as a leaving group for glycosylation and a selective and acid sensitive protecting group respectively. This versatile donor, while forming exclusive a-glycoside with serine/threonine, serves as a fascile precur
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## Summarv: A novel and efficient synthesis of 2,6-dideoxy-a-glycosides was developed by use of phenyl 2,6-anhydro-1,2-dithio-D-altropyranosides as glycosyl donors in a highly stereocontrolled glycosyla tion . Highly stereocontrolled synthesis of 2,6-dideoxy glycosides is of considerable interest