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A novel method for purification of recombinant adenoassociated virus vectors on a large scale

✍ Scribed by Xiaobing Wu; Xiaoyan Dong; Zhijian Wu; Hui Cao; Dongbin Niu; Jianguo Qu; Hong Wang; Yunde Hou

Publisher
Springer
Year
2001
Tongue
English
Weight
699 KB
Volume
46
Category
Article
ISSN
1001-6538

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## Abstract ## Background One of the major limitations to the use of adeno‐associated virus (AAV) vectors for gene therapy has been the difficulty in producing enough vector to supply a clinical trial. More than 20 000 roller bottles may be required to generate AAV by the traditional transient tra