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A Novel Metalloprotease in Rat Brain Cleaves the Amyloid Precursor Protein of Alzheimer's Disease Generating Amyloidogenic Fragments †

✍ Scribed by Mok, Su San; Evin, Geneviève; Li, Qiao-Xin; Smith, A. Ian; Beyreuther, Konrad; Masters, Colin L.; Small, David H.

Book ID: 126154071
Publisher: American Chemical Society
Year: 1997
Tongue: English
Weight: 252 KB
Volume: 36
Category: Article
ISSN: 0006-2960
DOI: 10.1021/bi961848w

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## Abstract Proteolytic processing of the amyloid precursor protein by β ‐and γ‐secretases results in the production of Alzheimer's disease (AD) Aβ amyloid peptides. Modulation of secretase activity is being investigated as a potential therapeutic approach. Recent studies with human brain have reve