๐”– Bobbio Scriptorium
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A novel mechanism underlying drug resistance in chronic epilepsy

โœ Scribed by Stefan Remy; Siegrun Gabriel; Bernd W. Urban; Dirk Dietrich; Thomas N. Lehmann; Christian E. Elger; Uwe Heinemann; Heinz Beck

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
506 KB
Volume
53
Category
Article
ISSN
0364-5134

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Reduced folate carrier mutations are not
Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia
โœ Yotam Kaufman; Stavit Drori; Peter D. Cole; Barton A. Kamen; Jenny Sirota; Ilan ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 257 KB

## Abstract ## BACKGROUND Although the majority of children with acute lymphoblastic leukemia (ALL) are cured with combination chemotherapy containing methotrexate (MTX), drug resistance contributes to treatment failure for a substantial fraction of patients. The primary transporter for folates an