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A Novel Mechanism of Voltage Sensing and Gating in K2P Potassium Channels

โœ Scribed by Schewe, Marcus; Rapedius, Markus; Nematian-Ardestani, Ehsan; Linke, Thomas; Benndorf, Klaus; Tucker, Stephen J.; Baukrowitz, Thomas

Book ID
123499562
Publisher
Biophysical Society
Year
2014
Tongue
English
Weight
40 KB
Volume
106
Category
Article
ISSN
0006-3495

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We have cloned a novel voltage-gated K channel, LKv1, in two species of leech. The properties of LKv1 expressed in transiently transfected HEK293 cells is that of a delayed rectifier current. LKv1 may be a major modulator of excitability in leech neurons, since antibody localization studies show tha