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A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1

✍ Scribed by Eran Nadav; Ayelet Shmueli; Haim Barr; Hedva Gonen; Aaron Ciechanover; Yuval Reiss


Book ID
117053498
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
449 KB
Volume
303
Category
Article
ISSN
0006-291X

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## Abstract BAG‐1 (Bcl‐2 associated athanogene‐1) is a multifunctional protein, linking cell proliferation, cell death, protein folding, and cell stress. In vivo, BAG‐1 is expressed in growth plate and articular cartilage, and the expression of BAG‐1 is decreased with aging. Chondrocytes respond to