A novel low-friction surface for biomedical applications: Modification of poly(dimethylsiloxane) (PDMS) with polyethylene glycol(PEG)-DOPA-lysine
✍ Scribed by Kanika Chawla; Seunghwan Lee; Bruce P. Lee; Jeffrey L. Dalsin; Phillip B. Messersmith; Nicholas D. Spencer
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 308 KB
- Volume
- 90A
- Category
- Article
- ISSN
- 1549-3296
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✦ Synopsis
Abstract
Aqueous biocompatible tribosystems are desirable for a variety of tissue‐contacting medical devices. L‐3,4‐dihydroxyphenylalanine (DOPA) and lysine (K) peptide mimics of mussel adhesive proteins strongly interact with surfaces and may be useful for surface attachment of lubricating polymers in tribosystems. Here, we describe a significant improvement in lubrication properties of poly (dimethylsiloxane) (PDMS) surfaces when modified with PEG‐DOPA‐K. Surfaces were characterized by optical and atomic force microscopy, contact angle, PM‐IRRAS, and X‐ray photoelectron spectroscopy. Such surfaces, tested over the course of 200 rotations (∼8 m in length), maintained an extremely low friction coefficient (μ) (0.03 ± 0.00) compared to bare PDMS (0.98 ± 0.02). These results indicate the potential applications of PEG‐DOPA‐K for the modification of device surfaces. Extremely low μ values were maintained over relatively long length scales and a range of sliding speeds without the need for substrate pre‐activation and in the absence of excess polymer in aqueous solution. These results were only obtained when DOPA was bound to lysine (modification with PEG‐DOPA did not have an effect on μ) suggesting the critical role of lysine in obtaining a lowered friction coefficient. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009