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A novel isocoumarin derivative induces mitotic phase arrest and apoptosis of human multiple myeloma cells

✍ Scribed by Takeshi Kawano; Naoki Agata; Surender Kharbanda; David Avigan; Donald Kufe


Book ID
105992435
Publisher
Springer
Year
2006
Tongue
English
Weight
586 KB
Volume
59
Category
Article
ISSN
0344-5704

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## Abstract Bisphosphonates (BPs) are widely used in the treatment of osteolytic bone disease associated with multiple myeloma, and have been demonstrated to exert antitumor effects both __in vitro__ and __in vivo__. However, the precise molecular mechanisms involved in the direct antitumor effects