A novel interaction between the human papillomavirus type 16 E2 and E1^E4 proteins leads to stabilization of E2
β Scribed by Clare Davy; Pauline McIntosh; Deborah J. Jackson; Rina Sorathia; Matthew Miell; Qian Wang; Jameela Khan; Yasmina Soneji; John Doorbar
- Book ID
- 113947961
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 530 KB
- Volume
- 394
- Category
- Article
- ISSN
- 0042-6822
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Publication of the International Union Against Cancer Publication de I'Union lnternationale Contre 1e Cancer
## Abstract The E2 protein of the papillomavirus plays an essential role in the viral life cycle. Through a yeast twoβhybrid screening, human poloβlike kinase 1 was found to interact with human papillomavirus type 5 E2. Further characterization identified that the domains responsible for the intera
## Abstract Human papillomavirus (HPV) infection is associated with cervical cancer. The E2 and E1 papillomavirus proteins are expressed at the early stage of infection and regulate DNA replication. The E2 protein activates and represses transcription from different HPVs promoters. At some stage wh