A Novel Human Artificial Chromosome Vector Provides Effective Cell Lineage–Specific Transgene Expression in Human Mesenchymal Stem Cells
✍ Scribed by Xianying Ren; Motonobu Katoh; Hidetoshi Hoshiya; Akihiro Kurimasa; Toshiaki Inoue; Fumiaki Ayabe; Kotaro Shibata; Junya Toguchida; Mitsuo Oshimura
- Book ID
- 111843536
- Publisher
- AlphaMed Press
- Year
- 2005
- Tongue
- English
- Weight
- 317 KB
- Volume
- 23
- Category
- Article
- ISSN
- 1066-5099
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract ## Background Human mesenchymal stem cells (hMSC) are increasingly the focus of both basic and clinical research due to their ability to strike a balance between self‐renewal and commitment to mesodermal differentiation. However, the promising therapeutic utility of hMSC in regenerativ
## Abstract ## Background The ability of human mesenchymal stem cells (hMSCs) to differentiate into specific cells holds promise for therapeutic use in cell‐ or gene‐based therapy. Genetic modification of hMSCs by introduction of therapeutic genes is an important tool for successful cell‐mediated
Background Herpes simplex virus type-1 (HSV-1) amplicon vectors are attractive tools for gene transfer because of their large DNA insert capacity, their broad host range of vector transduction and a minimal immune response as a result of the absence of helper viruses during viral packaging. However,