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A novel highly stereoselective total synthesis of epothilone B and of its (12R,13R) acetonide

✍ Scribed by Johann Mulzer; Gunter Karig; Peter Pojarliev

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 91 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01318-6

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✦ Synopsis

Stereoselective syntheses of epothilone B (1) and its novel derivative 2 are described. Key steps are the formation of intermediate 3 via Sharpless AD-reaction and Davis-Evans-hydroxylation.

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