A novel hemin reducing system: Crown ether complexes of sodium dithionite and their uses as reducing agents in nonaqueous solvents
✍ Scribed by Terry Mincey; T.G. Traylor
- Publisher
- Elsevier Science
- Year
- 1978
- Weight
- 687 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0006-3061
No coin nor oath required. For personal study only.
✦ Synopsis
The &pa&on of an i&rown4+omplex of &diui =dithioniie is iit5 scribed. This co&pIex is sohibl6 & DMF, DMSO, al&h& and &her solve& , and allows diH$onite to be used as a reducing -igent in solvents~in &hi&& ii otherwise i&Iub!e. The com@lex easily iedti&s_a new chelated protohe&&& nonaqueous media and, in aprotic s&vents, it selectively reduces the hem@.
in the presence of-oxygen, yiehiing Be pxyheme-derivative, In addition, the reduction of both +zobenzene and disuEde bonds in organic_solvents further &%on+ate~ the utility of thenew complex. mu ,--_ 6 X 1O-g M [8], and kd is variously estimated to be 40 set-l to 1.7 see-l
[9,101-Most of the reducing power of sodium dithionite has been shown to be due to the free-radical anion, but the undissociated form could be active as well.
This report describes the preparation of crown ether complexes of sodium dithionite and their use as reductants in organic solvents.
EXPERIMENTAL SECTION
AlI solvents used were reagent grade. Sodium dithionite was purchased from J. T. Baker. Crown ethers were obtained from Aldrich Chemical Co. or Parish Chemical Co. Pllmans reagent was obtained from Pierce Chemical Co.
Nuclear magnetic resonance spectra were obtained on a Varian PM-390 spec-