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A Novel Functional Class of Pore-Forming Peptides

โœ Scribed by Wiedman, Gregory; Fuselier, Taylor; He, Jing; Searson, Peter; Hristova, Kalina; Wimley, William C.

Book ID
122292146
Publisher
Biophysical Society
Year
2014
Tongue
English
Weight
62 KB
Volume
106
Category
Article
ISSN
0006-3495

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We have developed a visual microwell plate assay for rapid, high-throughput screening for membrane-disrupting molecules such as de novo designed pore formers, antibiotic peptides, bacterial toxins, and lipases. The detectability is based on the strong fluorescence emission of the lanthanide metal te