A novel function of CD82/KAI-1 on E-cadherin-mediated homophilic cellular adhesion of cancer cells
โ Scribed by Masakazu Abe; Tsuyoshi Sugiura; Miho Takahashi; Kotaro Ishii; Miyuki Shimoda; Kanemitsu Shirasuna
- Book ID
- 116334728
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 738 KB
- Volume
- 266
- Category
- Article
- ISSN
- 0304-3835
No coin nor oath required. For personal study only.
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## Abstract The cellโsurface glycoprotein KAI1 suppresses tumor growth and metastasis in various animal models. Downregulation of KAI1 has been implicated in the progression of cancer. However, the mechanisms of KAI1 inactivation are poorly understood. This is the first study that investigates expr
With interest I read the article by Christgen et al. that was recently published under the Fast Track heading in the International Journal of Cancer. 1 The major reported findings, nicely summarized in the article's title, are that (a) KAI1/CD82 is downregulated in 77% of human breast carcinomas and