𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A Novel Extravascular Input Function for the Assessment of Drug Absorption in Bioavailability Studies

✍ Scribed by Michael Weiss


Book ID
110344473
Publisher
Springer US
Year
1996
Tongue
English
Weight
992 KB
Volume
13
Category
Article
ISSN
0724-8741

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Pharmacokinetics of pafenolol in the rat
✍ Hans Lenneras; Carl G. RegΓ₯rdh πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 559 KB

The pharmacokinetics of pafenolol, a highly selective /?,-adrenoceptor antagonist, have been studied in starved and unstarved rats. Separate groups received intravenous doses (0.3 and 3.0pmol kg-I) and oral doses (1 and 25pmol kg-I). The systemic clearance of pafenolol was constant in the dose range

Evaluation of a chronically isolated int
✍ Fred G. J. Poelma; Josef J. Tukker πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 English βš– 470 KB

A model is described to study absorption kinetics of drugs in the unanesthetized rat. The surgical technique consists of a long-term isolation of an intestinal segment inside the animal. This isolated loop is used in perfusion experiments. In this model the effects of anesthesia and surgical trauma

In Vitro absorption and secretory quotie
✍ Victoria E. Thiel-Demby; Timothy K. Tippin; Joan E. Humphreys; Cosette J. Serabj πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 92 KB πŸ‘ 1 views

The absorptive (AQ) and secretory (SQ) quotients have been proposed as a novel experimental approach to quantify the modulation of intestinal absorption and secretion by P-glycoprotein (Pgp). Because these unidirectional assays inherently assess for the impact of Pgp, conclusions as to whether a com