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A novel exon in AML1-ETO negatively influences the clonogenic potential of the t(8;21) in acute myeloid leukemia

✍ Scribed by Mannari, D; Gascoyne, D; Dunne, J; Chaplin, T; Young, B


Book ID
109887042
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
296 KB
Volume
24
Category
Article
ISSN
0887-6924

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Simple variant t(8;21) acute myeloid leu
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We report on the molecular characterization of two acute myeloid leukemias (AML), one AML-M1 (patient 1) and one AML-M2 (patient 2) with t(8;21)(p21;q22) and t(8;20)(q22;p13), respectively, at diagnosis. The locations of the breakpoints, 21q22 in patient 1 and 8q22 in patient 2, prompted us to searc