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A novel DNA cleaving agent, 2,2′-bis(2-aminoethyl)-4,4′-bithiazole, induces thymocyte apoptosis

✍ Scribed by Eibai Lee; Fumiko Miyaguchi; Maho Inoue; Kimio Kariya; Hideaki Sasaki

Book ID
111742147
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
386 KB
Volume
40
Category
Article
ISSN
1521-6543

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✍ Hideaki Sasaki 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 276 KB

In the site specific strand scission of DNA by bleomycin, 2.4'-bithiazole moiety with a positive charge center has played a key role to interact with DNA double strand. 1) As a part of distamycin analog, the thiazole moiety linked by amide bond to N-methylpyrrole rings could be used as a recognition