A Novel Dimeric Coumarin Analog and Antimycobacterial Constituents from Fatoua pilosa

✍ Scribed by Chun-Ching Chiang; Ming-Jen Cheng; Chien-Fang Peng; Hung-Yi Huang; Ih-Sheng Chen

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 247 KB
• Volume: 7
• Category: Article
• ISSN: 1612-1872
• DOI: 10.1002/cbdv.200900326

✦ Synopsis

Abstract

One novel dimeric coumarin analog, fatouapilosin (1), together with 18 known compounds, have been isolated from the whole plants of Fatoua pilosa. The structures of these isolates were elucidated by means of spectroscopic techniques (UV, IR, MS, ^1^H‐ and ^13^C‐NMR, DEPT, COSY, NOESY, HSQC, HMBC, and MS analyses). Among the tested compounds 2–14, scopoletin (3), isobavachalcone (12), and (E)‐1‐[2,4‐dihydroxy‐3‐(3‐methylbut‐2‐enyl)phenyl]‐3‐(2,2‐dimethyl‐8‐hydroxy‐2__H__‐benzopyran‐6‐yl)prop‐2‐en‐1‐one (14) exhibited the strongest antimycobacterial activities against Mycobacterium tuberculosis H~37~Rv, with MIC values of 42, 18, and 30 μg/ml, respectively.