A novel dealkylation affording 3-aminoimidazo[1,2-a]pyridines: access to new substitution patterns by solid-phase synthesis

✍ Scribed by Christopher Blackburn; Bing Guan

• Book ID: 104209940
• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 206 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)00003-4

✦ Synopsis

The three-component synthesis of 3-aminoimidazo[1,2-a]pyridine derivatives has been extended by a novel acidinduced dealkyation reaction that removes the 1,1,3,3-tetramethylbutyl group derived from the isonitrile input. This reaction was conducted on the solid-phase using the HMBA linker and the resulting products subjected to reductive alkylation using several aldehydes, thereby accessing novel substitution patterns at the 3-position.