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A novel de novo mutation in LKB1 gene in a Chinese Peutz Jeghers syndrome patient significantly diminished p53 activity

✍ Scribed by Lin Liu; Xiaohui Du; Jing Nie


Book ID
119218326
Publisher
Elsevier
Year
2011
Tongue
French
Weight
315 KB
Volume
35
Category
Article
ISSN
2210-7401

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Peutz-Jeghers syndrome (PJS) is a rare autosomal dominantly inherited disorder with variable expression and incomplete penetrance characterized by mucocutaneous pigmentation, predisposition to hamartomatous intestinal polyposis, and various other neoplasms. It occurs in approximately 1 in 8,300 to 2