A novel convenient one step pyrimidine synthesis

✍ Scribed by A.L. Weis; V. Rosenbach

• Publisher: Elsevier Science
• Year: 1981
• Tongue: French
• Weight: 118 KB
• Volume: 22
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)90348-x

✦ Synopsis

A new method for the preparation of pyrimidines by condensation of B-dicarbonyl compounds, ammonium salts and carbonyl containing substances has been developed.

An attractive approach to the synthesis of 1,2_dihydropyrimidines bearing alkyl or aryl groups consists of the reaction of B-dicarbonyl compounds, ammonium salts and carbonyl containing substances. 1,2_Dihydropyrimidines containing gem-dialkyl groups attached to the saturated carbon in position 2 of the pyrimidine ring have been prepared. l-3 These compounds are stable to further oxidation to pyrimidines because of the gem-disubstitution. New routes