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A novel controlled release drug delivery system for multiple drugs based on electrospun nanofibers containing nanoparticles

✍ Scribed by Yazhou Wang; Bochu wang; Weili Qiao; Tieying Yin

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 331 KB
Volume: 99
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.22189

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✦ Synopsis

This study describes development of a novel controlled drug release system for multiple drugs, it consisted of Chitosan nanoparticles/PCL composite electrospun nanofibers with core-sheath structures. Two model agents' rhodamine B and naproxen were successfully loaded in the core and sheath region respectively. The behavior of these two agents demonstrated a good controlled release and temporality, providing a new way to obtain program or temporality release for multiple agents. Particularly, this is potential applications in the field of tissue engineering, sutures and wound dressings.

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