A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host
✍ Scribed by Anton Bom; Mark Bradley; Ken Cameron; John K. Clark; Jan van Egmond; Helen Feilden; Elizabeth J. MacLean; Alan W. Muir; Ronald Palin; David C. Rees; Ming-Qiang Zhang
- Book ID
- 102679266
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 604 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
✦ Synopsis
4AD (UK) [**] The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A.
Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969 ± rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969 ± rocuronium complexation (Figure 2).