๐”– Bobbio Scriptorium
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A novel clonality assay based on transcriptional analysis of the active X chromosome

โœ Scribed by Dr. Josef T. Prchal; Y. L. Guan

Book ID
112212514
Publisher
AlphaMed Press
Year
1993
Tongue
English
Weight
452 KB
Volume
11
Category
Article
ISSN
1066-5099

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Clonality of hematopoietic cells on a smale scale (nanogram amounts of DNA) can be detected by X-chromosome inactivation using the polymerase chain reaction (PCR). The human androgen-receptor gene (HUMARA) has a polymorphic short tandem repeat (STR), and has generally been used for clonality analysi

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## Studies of clonality have been essential for understanding the hierarchy of hematopoiesis and the biology of malignancies. Most clonality assays are based on the X chromosome inactivation phenomenon in females; these assays detect protein polymorphisms, differences in DNA methylation, or transcr