A Novel Class of Oral Direct Renin Inhibitors: Highly Potent 3,5-Disubstituted Piperidines Bearing a Tricyclic P 3– P 1 Pharmacophore

✍ Scribed by Ostermann, Nils; Ruedisser, Simon; Ehrhardt, Claus; Breitenstein, Werner; Marzinzik, Andreas; Jacoby, Edgar; Vangrevelinghe, Eric; Ottl, Johannes; Klumpp, Martin; Hartwieg, J. Constanze D.; Cumin, Frederic; Hassiepen, Ulrich; Trappe, Jörg; Sedrani, Richard; Geisse, Sabine; Gerhartz, Bernd; Richert, Paul; Francotte, Eric; Wagner, Trixie; Krömer, Markus; Kosaka, Takatoshi; Webb, Randy L.; Rigel, Dean F.; Maibaum, Jürgen; Baeschlin, Daniel K.

• Book ID: 119939286
• Publisher: American Chemical Society
• Year: 2013
• Tongue: English
• Weight: 851 KB
• Volume: 56
• Category: Article
• ISSN: 0022-2623
• DOI: 10.1021/jm301706j