✦ LIBER ✦
A Novel Class of Ferrocenyl-Aryl-Based Diphosphine Ligands for Rh- and Ru-Catalysed Enantioselective Hydrogenation
✍ Scribed by Thomas Sturm; Walter Weissensteiner; Felix Spindler
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 122 KB
- Volume
- 345
- Category
- Article
- ISSN
- 1615-4150
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✦ Synopsis
Abstract
A series of diphosphines of the novel Walphos ligand family all based on a phenylferrocenylethyl backbone were synthesised in a four‐step sequence. In the rhodium‐ or ruthenium‐catalysed asymmetric hydrogenation of olefins and ketones enantioselectivities of up to 95% and 97%, respectively, were obtained. A 2‐isopropylcinnamic acid derivative of industrial interest was hydrogenated in 95% ee and with turnover numbers of >5000.