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A novel class of apical sodium co-dependent bile acid transporter inhibitors: the 2,3-disubstituted-4-phenylquinolines

✍ Scribed by Michael B. Tollefson; William F. Vernier; Horng-Chih Huang; Fang Ping Chen; Emily J. Reinhard; Judith Beaudry; Bradley T. Keller; David B. Reitz

Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
151 KB
Volume
10
Category
Article
ISSN
0960-894X

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✦ Synopsis

A series of 2,3-disubstituted-4-phenylquinolines were prepared and were found to inhibit the apical sodium co-dependent bile acid transporter (ASBT). Alkyl and ester substitution at the 3-position showed comparable activities while substitution at the 2-position was much more sensitive to the nature of the substituent. The synthesis and in vitro potency data are presented for this novel class of compounds.

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ChemInform Abstract: A Novel Class of Ap
ChemInform Abstract: A Novel Class of Apical Sodium Co-Dependent Bile Acid Transporter Inhibitors: The 2,3-Disubstituted-4-phenylquinolines.
✍ Michael B. Tollefson; William F. Vernier; Horng-Chih Huang; Fang Ping Chen; Emil πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 33 KB πŸ‘ 1 views

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