A short chemical process is described for the synthesis of optically active 3y roxy-4-alkoxycarbonyl-Z-azetidinones (R-lactams) from L-tartaric acid. Tartaric acid is an extremely useful and versatile member of the chiral pool. Since nearly any type of f+hydroxy acid can be converted to a 8-lactam (
A novel chemical transformation of 3-vinyl-4-substituted-2-azetidinones
โ Scribed by Ajay K Bose; Lalitha Krishnan; Dilip R Wagle; Magnar S Manhas
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 235 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
The regioselective nitroso Diels-Alder (NDA) cycloadditions of 3-dienyl-2-azetidinones with nitrosobenzene to generate oxazine-substituted b-lactams in excellent yields are reported. The amidiolytic ring opening of the cycloadducts with sodium methoxide followed by iodocyclization using I 2 /K 2 CO
Chiral 5,6-disubstituted-5,6-dihydro-2(1H)-pyridones were prepared efficiently from readily accessible 3,4-disubstituted-2-azetidinones having preadjusted substituents and stereochemistry through the reductive ring opening of 2-azetidinones followed by Z-selective installation of acetate moiety and