A novel central motor conduction abnormality in D90A-homozygous patients with amyotrophic lateral sclerosis
โ Scribed by Abena D. Osei-Lah; Martin R. Turner; Peter M. Andersen; P. Nigel Leigh; Kerry R. Mills
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 134 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0148-639X
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๐ SIMILAR VOLUMES
The following data were obtained on 21 amyotrophic lateral sclerosis (ALS) patients, aged 36-76 years (mean: 58 years), at baseline and months 4, 8, and 12: thenar motor unit number estimate (MUNE) using multiple point stimulation, mean thenar surface-recorded motor unit action potential negative-pe
## Abstract Approximately 10% of amyotrophic lateral sclerosis (ALS) cases are familial, and the Cu/Zn superoxide dismutase (SOD1) gene mutation accounts for 20% of them. More than 100 SOD1 mutations have been described, some with peculiar phenotypes. Moreover, mutations in the SOD1 gene have been