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A novel bisphosphonate minodronate (YM529) specifically inhibits osteolytic bone metastasis produced by human small-cell lung cancer cells in NK-cell depleted SCID mice

✍ Scribed by Helong Zhang; Seiji Yano; Toyokazu Miki; Hisatsugu Goto; Takanori Kanematsu; Hiroaki Muguruma; Hisanori Uehara; Saburo Sone

Book ID
110423019
Publisher
Springer
Year
2003
Tongue
English
Weight
200 KB
Volume
20
Category
Article
ISSN
0262-0898

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Parathyroid hormone-related protein (PTH
Parathyroid hormone-related protein (PTHrP) is responsible for production of bone metastasis, but not visceral metastasis, by human small cell lung cancer SBC-5 cells in natural killer cell-depleted SCID mice
✍ Toyokazu Miki; Seiji Yano; Masaki Hanibuchi; Takanori Kanematsu; Hiroaki Mugurum 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 116 KB

## Abstract We previously established an osteolytic bone metastasis model with multiorgan dissemination in natural killer (NK) cell‐depleted severe combined immunodeficient (SCID) mice using human small cell lung cancer cells (SBC‐5), which highly express the parathyroid hormone‐related protein (PT