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A novel biomaterial for osteotropic drug nanocarriers: synthesis and biocompatibility evaluation of a PLGA–ALE conjugate

✍ Scribed by Pignatello, Rosario; Cenni, Elisabetta; Micieli, Dorotea; Fotia, Caterina; Salerno, Manuela; Granchi, Donatella; Avnet, Sofia; Sarpietro, Maria G; Castelli, Francesco; Baldini, Nicola


Book ID
120083347
Publisher
Future Medicine
Year
2009
Tongue
English
Weight
842 KB
Volume
4
Category
Article
ISSN
1743-5889

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## Abstract The synthesis of the novel pentagastrin seco‐CBI conjugate **3**, which is based on the highly cytotoxic antitumor antibiotic (+)‐duocarmycin SA (**1**), is reported. A key step in the synthesis is the palladium‐catalyzed carbonylation of aryl bromide **7** to give the benzyl ester **16