A novel autosomal recessive nonsyndromic hearing impairment locus (DFNB42) maps to chromosome 3q13.31-q22.3

✍ Scribed by Muhammad Aslam; Muhammad Wajid; Maria H. Chahrour; Muhammad Ansar; Sayedul Haque; Thanh L. Pham; Regie P. Santos; Kai Yan; Wasim Ahmad; Suzanne M. Leal

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 78 KB
• Volume: 133A
• Category: Article
• ISSN: 1552-4825
• DOI: 10.1002/ajmg.a.30508

✦ Synopsis

A consanguineous family with autosomal recessive nonsyndromic hearing impairment (NSHI) was ascertained in Pakistan and displayed significant evidence of linkage to 3q13.31-q22.3. The novel locus (DFNB42) segregating in this kindred, maps to a 21.6 cM region according to a genetic map constructed using data from both the deCode and Marshfield genetic maps. This region of homozygosity is flanked by markers D3S1278 and D3S2453. A maximum multipoint LOD score of 3.72 was obtained at marker D3S4523. DFNB42 represents the third autosomal recessive NSHI locus to map to chromosome 3.