A novel approach to the histrionicotoxin framework
โ Scribed by Parsons, Philip J.; Angell, Richard; Naylor, Alan; Tyrell, Elizabeth
- Book ID
- 121208887
- Publisher
- The Royal Society of Chemistry
- Year
- 1993
- Tongue
- English
- Weight
- 198 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0022-4936
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๐ SIMILAR VOLUMES
Recent studies1 have resulted in a number of synthetic pathways to the useful neurotoxin uperhydrohistrionicotoxin. 2 We describe here a new entry into the histrionicotoxin ring system using a Mannich-type Spiro cyclization which eventually led to the synthesis of two new biologically interesting s
The viability of the key steps in our approach to the novel sesquiterpene breynolide (1) has hem verified by preparation of the hydrobenzothiophene 16. The sequence features a Diels-Alder reaction of 10 with 7 to load eventually to 13; subsequent dipolar cycloaddition of 13 with a functionalized nit