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A Novel Approach to Combretastatins: From trans-Epoxide to CA-4 and Its Dioxolane Derivative

โœ Scribed by Paolo Lupattelli; Maurizio D'Auria; Nadia Di Blasio; Francesca Lenti


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
145 KB
Volume
2009
Category
Article
ISSN
1434-193X

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Asymmetric Hetero Diels-Alder Reaction of N-Benzylimines Derived from ( R)-Glyceraldehyde: A New Approach to Homochiral Piperidine Building Blocks and Its Application to the Synthesis of (2R)-4-Oxopipecolic Acid. -The D-glyceraldehyde derived N-benzyl imine (I) undergoes a highly diastereoselective