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A novel anti-CD19 monoclonal antibody (GBR 401) with high killing activity against B cell malignancies

✍ Scribed by Breton, Caroline S; Nahimana, Aimable; Aubry, Dominique; Macoin, Julie; Moretti, Pierre; Bertschinger, Martin; Hou, Samuel; Duchosal, Michel A; Back, Jonathan


Book ID
125403609
Publisher
BioMed Central
Year
2014
Tongue
English
Weight
843 KB
Volume
7
Category
Article
ISSN
1756-8722

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## Abstract CD19 is an attractive therapeutic target for treating human B‐cell tumors. In our study, chimeric (c) divalent (cHD37) and tetravalent (cHD37‐DcVV) anti‐CD19 monoclonal antibodies (MAbs) were constructed, expressed and evaluated for their binding to human 19‐positive (CD19^+^) tumor cel