A novel and facile carbodiimide-mediated synthesis of 2,3-dihydro-6H-pyrimido[2,1-b]quinazolin-4(1H)-ones via a tandem intramolecular nucleophilic addition/intramolecular hetero conjugate addition annulation strategy

✍ Scribed by Takao Saito; Kensaku Tsuda

• Publisher: Elsevier Science
• Year: 1996
• Tongue: French
• Weight: 135 KB
• Volume: 37
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(96)02131-4

✦ Synopsis

A novel and efficient carbodiimide-mediated synthetic method for new 2,3-dihydro-6Hpyrimido[2,l-b]quinazolin-4(lH)-ones ( 4) is described which involves initial intramolecular addition of an amino-nucleophile to the carbodiimide-cumulenic system, followed by intramolecular hereto conjugate addition annulation.