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A Novel and Efficient Iodine(III)-Mediated Access to 1,4-Benzodiazepin-2-ones.

✍ Scribed by M. Teresa Herrero; Imanol Tellitu; Esther Dominguez; Isabel Moreno; Raul SanMartin


Book ID
101934825
Publisher
John Wiley and Sons
Year
2003
Weight
99 KB
Volume
34
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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A novel and efficient iodine(III)-mediat
✍ M.Teresa Herrero; Imanol Tellitu; Esther Domı́nguez; Isabel Moreno; RaΓΊl SanMart πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 126 KB

A novel access to 1,4-benzodiazepin-2-ones starting from glycine and alanine derivatives is described. The key cyclization step was performed by the action of phenyliodine(III)bis(trifluoroacetate) (PIFA) on the corresponding methoxyamide derivatives leading to the C(9a) N(1) bond construction. This