A novel and efficient iodine(III)-mediat
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M.Teresa Herrero; Imanol Tellitu; Esther DomΔ±Μnguez; Isabel Moreno; RaΓΊl SanMart
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Article
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2002
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Elsevier Science
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French
β 126 KB
A novel access to 1,4-benzodiazepin-2-ones starting from glycine and alanine derivatives is described. The key cyclization step was performed by the action of phenyliodine(III)bis(trifluoroacetate) (PIFA) on the corresponding methoxyamide derivatives leading to the C(9a) N(1) bond construction. This