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A novel and convenient method for the synthesis of substituted naphthostyrils

โœ Scribed by Jin-Jun Liu; Fred Konzelmann; Kin-Chun Luk

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
218 KB
Volume
44
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

3-Pyrrolyl-6-fluoro-naphthostyril 13 was synthesized via a base-catalyzed intramolecular cyclization of oxindole precursor 2 (Y=H). Derivatization of 2 (Y=I) through a one-pot reaction give 5-substituted naphthostyrils. This method allows convenient access to 3,5,6-trisubstituted naphthostyrils which may serve as a new template for CDK2 inhibition.

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