A Novel Algorithm for Validating Peptide Identification from a Shotgun Proteomics Search Engine
โ Scribed by Jian, Ling; Niu, Xinnan; Xia, Zhonghang; Samir, Parimal; Sumanasekera, Chiranthani; Mu, Zheng; Jennings, Jennifer L.; Hoek, Kristen L.; Allos, Tara; Howard, Leigh M.; Edwards, Kathryn M.; Weil, P. Anthony; Link, Andrew J.
- Book ID
- 119943018
- Publisher
- American Chemical Society
- Year
- 2013
- Tongue
- English
- Weight
- 545 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1535-3893
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A genetic algorithm-driven search method GAP1.0; Genetic . Algorithm Peptide search, version 1.0 has been developed for the computational exploration of peptide conformational space. The suitability of a variety of genetic algorithm operators was evaluated through representative calculations w x ลฝ .
## Abstract A combinatorial peptide library contains an enormous combination of amino acid sequences and drug candidates, but an effective screening strategy to identify a variety of bioactive peptides has yet to be established. In this article, a random hexapeptide library was screened to identify